Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling

Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling

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The cytokine IFNγ differentially impacts on tumors upon immune checkpoint blockade (ICB). Despite our understanding of downstream signaling events, less is known about regulation of its receptor (IFNγ-R1). With an unbiased genome-wide CRISPR/Cas9 screen for critical regulators of IFNγ-R1 cell surfac...

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Bibliographic Details
Main Authors: Altelaar, M. (Author), Altinok, S. (Author), Apriamashvili, G. (Author), Bleijerveld, O.B (Author), Boshuizen, J. (Author), D’Empaire Altimari, D. (Author), de Bruijn, B. (Author), Krijgsman, O. (Author), Ligtenberg, M.A (Author), Lin, C.-P (Author), Londino, J.D (Author), Oswalt, L.E (Author), Peeper, D.S (Author), Sanchez-Hodge, R. (Author), Schisler, J.C (Author), Traets, J.J.H (Author), van Vliet, A. (Author), Visser, N.L (Author), Vredevoogd, D.W (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
cell
degradation
enzyme activity
genetics
genome
human
Humans
metabolism
signal transduction
Signal Transduction
STUB1 protein, human
tumor
ubiquitin
Ubiquitin
ubiquitin protein ligase
ubiquitination
Ubiquitination
Ubiquitin-Protein Ligases
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