Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19

The SARS-CoV-2 3CL protease is a critical drug target for small molecule COVID-19 therapy, given its likely druggability and essentiality in the viral maturation and replication cycle. Based on the conservation of 3CL protease substrate binding pockets across coronaviruses and using screening, we id...

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Main Authors:	Bartolo-Cruz, M. (Author), Bednarova, E. (Author), Chavez, A. (Author), Daniels, J.D (Author), Farina, M. (Author), Forouhar, F. (Author), Fowler, B. (Author), Ho, D.D (Author), Hong, S.J (Author), Huang, Y. (Author), Hurst, B.L (Author), Iketani, S. (Author), Jurtschenko, C. (Author), Karan, C. (Author), Khanizeman, N. (Author), Lauber, M.A (Author), Lee, S. (Author), Li, W. (Author), Liu, H. (Author), McDonald, T. (Author), Mohri, H. (Author), Nair, M.S (Author), Quinn, C. (Author), Rajbhandari, P. (Author), Resnick, S.J (Author), Rovis, T. (Author), Shion, H. (Author), Stockwell, B.R (Author), Stokes, M.E (Author), Tay, N.E.S (Author), Xia, X. (Author), Zask, A. (Author)
Format:	Article
Language:	English
Published:	Nature Research 2022
Online Access:	View Fulltext in Publisher

by Bartolo-Cruz, M., Bednarova, E., Chavez, A., Daniels, J.D, Farina, M., Forouhar, F., Fowler, B., Ho, D.D, Hong, S.J, Huang, Y., Hurst, B.L, Iketani, S., Jurtschenko, C., Karan, C., Khanizeman, N., Lauber, M.A, Lee, S., Li, W., Liu, H., McDonald, T., Mohri, H., Nair, M.S, Quinn, C., Rajbhandari, P., Resnick, S.J, Rovis, T., Shion, H., Stockwell, B.R, Stokes, M.E, Tay, N.E.S, Xia, X., Zask, A.
Published 2022

View Fulltext in Publisher

Article

Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19

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