Anti-fibrotic mechanism of SPP1 knockdown in atrial fibrosis associates with inhibited mitochondrial DNA damage and TGF-β/SREBP2/PCSK9 signaling

Anti-fibrotic mechanism of SPP1 knockdown in atrial fibrosis associates with inhibited mitochondrial DNA damage and TGF-β/SREBP2/PCSK9 signaling

Atrial fibrosis occurs frequently with structural heart disease and is considered as a major cause of arrhythmia. Microarray-based profiling predicted the differential expression of SPP1 in atrial fibrosis. Herein, we aimed to analyze the role of shRNA-mediated SPP1 knockdown in the progression of a...

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Bibliographic Details
Main Authors: Chu, H. (Author), Du, X. (Author), Feng, M. (Author), Fu, G. (Author), He, B. (Author), Liu, J. (Author), Liu, T. (Author), Shen, C. (Author), Wang, B. (Author), Xu, Y. (Author), Zhuo, W. (Author)
Format: Article
Language:English
Published: Springer Nature 2022
Online Access:View Fulltext in Publisher

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