Mycobacterium tuberculosis DosS binds H2S through its Fe3+ heme iron to regulate the DosR dormancy regulon

Mycobacterium tuberculosis DosS binds H2S through its Fe3+ heme iron to regulate the DosR dormancy regulon

Mycobacterium tuberculosis (Mtb) senses and responds to host-derived gasotransmitters NO and CO via heme-containing sensor kinases DosS and DosT and the response regulator DosR. Hydrogen sulfide (H2S) is an important signaling molecule in mammals, but its role in Mtb physiology is unclear. We have p...

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Bibliographic Details
Main Authors: Alipour, E. (Author), Basu, S. (Author), Estrin, D.A (Author), Glasgow, J.N (Author), Kim-Shapiro, D.B (Author), Lancaster, J.R., Jr (Author), Marti, M.A (Author), Pettinati, M. (Author), Reddy, V.P (Author), Sevalkar, R.R (Author), Steyn, A.J.C (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2022
Subjects:
Dormancy regulon
DosS
Hydrogen sulfide
Tuberculosis
Two-component system
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