Head and neck cancer organoids established by modification of the CTOS method can be used to predict in vivo drug sensitivity

Objectives: Currently there are no standard biomarkers of head and neck squamous cell carcinoma (HNSCC) response to therapy. This is, due to a lack of adequate predictive tumor models. To this end, we established cancer organoid lines from individual patient's tumors, and characterized their gr...

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Bibliographic Details
Main Authors:	Lindemann, A. (Author), Myers, J.N (Author), Osman, A.A (Author), Patel, A.A (Author), Takahashi, H. (Author), Takahashi, Y. (Author), Tanaka, N. (Author), Zhao, M. (Author)
Format:	Article
Language:	English
Published:	Elsevier Ltd 2018
Subjects:	3D culture animal animal cell animal experiment Animals antineoplastic agent Antineoplastic Agents Article body weight buccal mucosa Cancer organoid cancer patient cancer survival cancer tissue cancer tissue originated spheroid Cancer tissue-originated spheroid (CTOS) cell survival cetuximab cisplatin Cisplatin clinical article clonogenic assay colon cancer DNA extraction docetaxel Docetaxel drug effect drug screening Drug Screening Assays, Antitumor drug sensitivity Drug sensitivity assay eosin epithelium cell female Female gene sequence genomic DNA genotype gingiva Head and neck cancer Head and Neck Neoplasms head and neck squamous cell carcinoma head and neck squamous cell carcinoma cell line head and neck tumor hematoxylin histology hms001 cell line HPV-positive human human cell human tissue Humans IC50 immunohistochemistry in vitro study Inhibitory Concentration 50 Langerhans cell larynx lung cancer macrophage male Male Mice mouse multicellular spheroid nonhuman oncological procedure organoid Organoids pathology perineural invasion pharynx prediction primary cell culture Primary Cell Culture priority journal procedures protein p53 Spheroids, Cellular Squamous Cell Carcinoma of Head and Neck tongue tonsil treatment response tumor cell tumor cell culture Tumor Cells, Cultured tumor localization tumor marker tumor volume um scc 47 cell line Wart virus Western blotting WSU-HN30 cell line Xenograft Model Antitumor Assays
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Head and neck cancer organoids established by modification of the CTOS method can be used to predict in vivo drug sensitivity

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