Event-related brain potential indexes provide evidence for some decline in healthy people with subjective memory complaints during target evaluation and response inhibition processing

• Main Authors: Fernando, D. (Author), Mónica, L. (Author), Susana, C.-F (Author)
• Format: Article
• Language: English
• Published: Academic Press Inc. 2021
• Subjects: adult; aged; Aged; Aged, 80 and over; Alzheimer disease; Alzheimer's Disease (AD); Article; attention; Attention; clinical article; cognitive defect; Cognitive Dysfunction; controlled study; electroencephalography; Electroencephalography; event related potential; Event-related potentials (ERPs); Evoked Potentials; evoked response; female; Female; Healthy Volunteers; human; Humans; inhibition (psychology); male; Male; memory; Memory; memory disorder; middle aged; Middle Aged; neuropsychological test; Neuropsychological Tests; normal human; pathophysiology; physiology; psychomotor performance; Psychomotor Performance; reaction time; Response inhibition; Stimulus evaluation; stimulus response; Subjective memory complaints (SMCs); task performance; very elderly
• Online Access: View Fulltext in Publisher
• ISBN: 10747427 (ISSN)
• DOI: 10.1016/j.nlm.2021.107450

In the preclinical stage of the Alzheimer's disease (AD) continuum, subjects report subjective memory complaints (SMCs), although with the absence of any objective decline, and have a higher risk of progressing to dementia than the general population. Early identification of this stage therefore constitutes a major focus of current AD research, to enable early intervention. In this study, healthy adult participants with high and low SMCs (HSMCs and LSMCs) performed a Go/NoGo task during electroencephalogram (EEG) recording. Relative to LSMC participants, HSMC participants performed the task slower (longer reaction times) and showed changes in the event-related potential (ERP) components associated with response preparation (lower readiness potential -RP- amplitude in the Go condition), and also related to response inhibition processes (lower N2-P3 amplitude in the NoGo condition). In addition, HSMC participants showed lower Go-N2 and NoGo-N2 peak-to-baseline amplitudes, however these results seem to be influenced by a negative tendency overlapping stimulus-related waveforms. The declines observed in this study are mostly consistent with those observed in aMCI participants, supporting the notion of the AD continuum regarding SMC state. © 2021 The Author(s)