Pancreatic cancer growth promoted by bone marrow mesenchymal stromal cell–derived IL-6 is reversed predominantly by IL-6 blockade

Pancreatic cancer growth promoted by bone marrow mesenchymal stromal cell–derived IL-6 is reversed predominantly by IL-6 blockade

Pancreatic cancer is a highly lethal cancer characterized by local invasiveness, early metastasis, recurrence and high resistance to current therapies. Extensive stroma or desmoplasia is a key histological feature of the disease, and interactions between cancer and stromal cells are critical for pan...

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Bibliographic Details
Main Authors:	Antoon, R. (Author), Hedley, D.W (Author), Keating, A. (Author), Saleh, A.H (Author), Wang, X.-H (Author), Warrington, J. (Author)
Format:	Article
Language:	English
Published:	Elsevier B.V. 2022
Subjects:	animal Animals bone marrow Bone Marrow Cell Line, Tumor genetics human Humans interleukin 6 interleukin-6 Interleukin-6 mesenchymal stem cell Mesenchymal Stem Cells mesenchymal stromal cells metabolism Mice mouse MSC pancreas tumor pancreatic cancer Pancreatic Neoplasms STAT3 tumor cell line tumor microenvironment Tumor Microenvironment tumor stroma Vascular Endothelial Growth Factor A vasculotropin A
Online Access:	View Fulltext in Publisher

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