Association of pharmacist counseling with adherence, 30-day readmission, and mortality: A systematic review and meta-analysis of randomized trials

Objective(s): To determine the association of pharmacist medication counseling with medication adherence, 30-day hospital readmission, and mortality. Methods: The initial search identified 21,590 citations. After applying the inclusion and exclusion criteria, 62 randomized controlled trials (RCTs) (...

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Bibliographic Details
Main Authors: Bullers, K. (Author), Ho, M.-J (Author), Kelly, W.N (Author), Klocksieben, F. (Author), Kumar, A. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2021
Subjects:
Online Access:View Fulltext in Publisher
LEADER 02970nam a2200541Ia 4500
001 10.1016-j.japh.2021.01.028
008 220427s2021 CNT 000 0 und d
020 |a 15443191 (ISSN) 
245 1 0 |a Association of pharmacist counseling with adherence, 30-day readmission, and mortality: A systematic review and meta-analysis of randomized trials 
260 0 |b Elsevier B.V.  |c 2021 
856 |z View Fulltext in Publisher  |u https://doi.org/10.1016/j.japh.2021.01.028 
520 3 |a Objective(s): To determine the association of pharmacist medication counseling with medication adherence, 30-day hospital readmission, and mortality. Methods: The initial search identified 21,590 citations. After applying the inclusion and exclusion criteria, 62 randomized controlled trials (RCTs) (49 for the meta-analysis) were included in the final analysis. Data were pooled using a random-effects model. Results: The participants in most of the studies were older patients with chronic diseases who, therefore, were taking many drugs. The overall methodologic quality of evidence ranged from low to very low. Pharmacist medication counseling versus no such counseling was associated with a statistically significant 30% increase in relative risk (RR) for medication adherence, a 24% RR reduction in 30-day hospital readmission (number needed to treat = 4.2), and a 30% RR reduction in emergency department visits. RR reductions for primary care visits and mortality were not statistically significant. Conclusion: The evidence supports pharmacist medication counseling to increase medication adherence and to reduce 30-day hospital readmissions and emergency department visits. However, higher-quality RCT studies are needed to confirm or refute these findings. © 2021 American Pharmacists Association® 
650 0 4 |a adult 
650 0 4 |a aged 
650 0 4 |a Article 
650 0 4 |a counseling 
650 0 4 |a counseling 
650 0 4 |a Counseling 
650 0 4 |a Emergency Service, Hospital 
650 0 4 |a emergency ward 
650 0 4 |a female 
650 0 4 |a hospital emergency service 
650 0 4 |a hospital readmission 
650 0 4 |a human 
650 0 4 |a Humans 
650 0 4 |a male 
650 0 4 |a medication compliance 
650 0 4 |a meta analysis 
650 0 4 |a middle aged 
650 0 4 |a mortality 
650 0 4 |a outcome assessment 
650 0 4 |a Patient Readmission 
650 0 4 |a pharmacist 
650 0 4 |a Pharmacists 
650 0 4 |a primary medical care 
650 0 4 |a randomized controlled trial (topic) 
650 0 4 |a randomized controlled trial (topic) 
650 0 4 |a Randomized Controlled Trials as Topic 
650 0 4 |a risk factor 
650 0 4 |a sensitivity analysis 
650 0 4 |a systematic review 
650 0 4 |a very elderly 
700 1 |a Bullers, K.  |e author 
700 1 |a Ho, M.-J.  |e author 
700 1 |a Kelly, W.N.  |e author 
700 1 |a Klocksieben, F.  |e author 
700 1 |a Kumar, A.  |e author 
773 |t Journal of the American Pharmacists Association