Sodium para-aminosalicylic acid ameliorates lead-induced hippocampal neuronal apoptosis by suppressing the activation of the IP3R-Ca2+-ASK1-p38 signaling pathway

Sodium para-aminosalicylic acid ameliorates lead-induced hippocampal neuronal apoptosis by suppressing the activation of the IP3R-Ca2+-ASK1-p38 signaling pathway

Lead (Pb) is a naturally occurring heavy metal, which can damage the brain and affect learning and memory. Sodium para-aminosalicylic acid (PAS-Na), a non-steroidal anti-inflammatory drug, can readily cross the blood-brain barrier. Our previous studies have found that PAS-Na alleviated Pb-induced hip...

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Bibliographic Details
Main Authors: Aschner, M. (Author), Chen, J. (Author), Jiang, S.-Y (Author), Jiang, Y.-M (Author), Li, S.-J (Author), Li, Z.-C (Author), Peng, D.-J (Author), Wang, L.-L (Author), Zhao, L. (Author), Zhao, Y.-S (Author)
Format: Article
Language:English
Published: Academic Press 2022
Subjects:
ASK1-p38 pathway
Ca2+
IP3R
Lead
Neurotoxicity
PAS-Na
Online Access:View Fulltext in Publisher

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