Myotubularin-related phosphatase 5 is a critical determinant of autophagy in neurons

Myotubularin-related phosphatase 5 is a critical determinant of autophagy in neurons

Autophagy is a conserved, multi-step process of capturing proteolytic cargo in autophagosomes for lysosome degradation. The capacity to remove toxic proteins that accumulate in neurodegenerative disorders attests to the disease-modifying potential of the autophagy pathway. However, neurons respond o...

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Bibliographic Details
Main Authors: Barmada, S.J (Author), Bedi, K. (Author), Chua, J.P (Author), Colón-Mercado, J.M (Author), Kim, E.S (Author), Ljungman, M. (Author), McBride, J.P (Author), Paulsen, M.T (Author), Tank, E.M.H (Author), Ward, M.E (Author), Weisman, L.S (Author)
Format: Article
Language:English
Published: Cell Press 2022
Subjects:
autophagosome
induced pluripotent stem cells
iPSCs
macroautophagy
myotubularin
neuronal autophagy
optical pulse labeling
phosphoinositide
RNA stability
TDP-43
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