The role of natural antioxidants in cisplatin-induced hepatotoxicity
Cisplatin is a potent platinum-based anticancer drug approved by the Food Drug Administration (FDA) in 1978. Despite its advantages against solid tumors, cisplatin confers toxicity to various tissues that limit its clinical uses. In cisplatin-induced hepatotoxicity, few mechanisms have been identifi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier Masson s.r.l.
2021
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| Series: | Biomedicine and Pharmacotherapy
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| Subjects: | |
| Online Access: | View Fulltext in Publisher View in Scopus |
| LEADER | 02283nam a2200289Ia 4500 | ||
|---|---|---|---|
| 001 | 10.1016-j.biopha.2021.112328 | ||
| 008 | 220121s2021 CNT 000 0 und d | ||
| 020 | |a 07533322 (ISSN) | ||
| 245 | 1 | 0 | |a The role of natural antioxidants in cisplatin-induced hepatotoxicity |
| 260 | 0 | |b Elsevier Masson s.r.l. |c 2021 | |
| 490 | 1 | |a Biomedicine and Pharmacotherapy | |
| 650 | 0 | 4 | |a Cisplatin |
| 650 | 0 | 4 | |a Complementary medicine |
| 650 | 0 | 4 | |a Herbs |
| 650 | 0 | 4 | |a Liver damage |
| 650 | 0 | 4 | |a Natural products |
| 856 | |z View Fulltext in Publisher |u https://doi.org/10.1016/j.biopha.2021.112328 | ||
| 856 | |z View in Scopus |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116880220&doi=10.1016%2fj.biopha.2021.112328&partnerID=40&md5=5df5cd5a32931c5074d133f498972753 | ||
| 520 | 3 | |a Cisplatin is a potent platinum-based anticancer drug approved by the Food Drug Administration (FDA) in 1978. Despite its advantages against solid tumors, cisplatin confers toxicity to various tissues that limit its clinical uses. In cisplatin-induced hepatotoxicity, few mechanisms have been identified, which started as excess generation of reactive oxygen species that leads to oxidative stress, inflammation, DNA damage and apoptosis in the liver. Various natural products, plant extracts and oil rich in flavonoids, terpenoids, polyphenols, and phenolic acids were able to minimize oxidative stress by restoring the level of antioxidant enzymes and acting as an anti-inflammatory agent. Likewise, treatment with honey and royal jelly was demonstrated to decrease serum transaminases and scavenge free radicals in the liver after cisplatin administration. Medicinal properties of these natural products have a promising potential as a complementary therapy to counteract cisplatin-induced hepatotoxicity. This review concentrated on the protective role of several natural products, which has been proven in the laboratory findings to combat cisplatin-induced hepatotoxicity. © 2021 The Authors | |
| 700 | 1 | 0 | |a Abd Halim, S.A.S. |e author |
| 700 | 1 | 0 | |a Abd Rashid, N. |e author |
| 700 | 1 | 0 | |a Abdul Jalil, N.A. |e author |
| 700 | 1 | 0 | |a Adib Ridzuan, N.R. |e author |
| 700 | 1 | 0 | |a Budin, S.B. |e author |
| 700 | 1 | 0 | |a Hussan, F. |e author |
| 700 | 1 | 0 | |a Teoh, S.L. |e author |
| 773 | |t Biomedicine and Pharmacotherapy | ||