Differential expression of entorhinal cortex and hippocampal subfields α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors enhanced learning and memory of rats following administration of Centella asiatica

Differential expression of entorhinal cortex and hippocampal subfields α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors enhanced learning and memory of rats following administration of Centella asiatica

Centella asiatica (CA) is a widely used traditional herb, notably for its cognitive enhancing effect and potential to increase synaptogenesis. The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) and N-methyl-D-aspartate receptors (NMDARs) mediate fast excitatory neurotransmis...

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Bibliographic Details
Main Authors:	Abdullah, J.M (Author), Chuang, H.G (Author), Husin, S.S (Author), Ismail, N.H (Author), Jaafar, H. (Author), Mohamad, H. (Author), Mohd Yusuf Yeo, N.A.B (Author), Muthuraju, S. (Author), Reza, F. (Author), Senik, M.H (Author), Tengku Muhammad, T.S (Author), Wong, J.H (Author), Yusof, S.R (Author), Zhang, J. (Author)
Format:	Article
Language:	English
Published:	Elsevier Masson SAS 2019
Subjects:	4 aminobutyric acid A receptor alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid AMPA receptor AMPAR animal animal cell animal experiment Animals Article biosynthesis cell body Centella Centella asiatica Centella asiatica extract chromatography cognition cognitive neuroscience dendrite dose response Dose-Response Relationship, Drug drug effect drug megadose entorhinal cortex Entorhinal Cortex escape latency exploratory behavior gene expression Gene Expression genetics glutamate receptor 1 glutamate receptor 2 hippocampal CA1 region hippocampal CA3 region hippocampus Hippocampus histology immunochemistry immunohistochemistry ionotropic receptor isolation and purification Learning and memory locomotion Locomotion male Male memory memory test metabolism Morris water maze test n methyl dextro aspartic acid receptor nerve cell neurotransmission NMDAR nonhuman novel object recognition task open field test physiology plant extract Plant Extracts priority journal rat Rats Rats, Wistar Receptors, AMPA Receptors, N-Methyl-D-Aspartate recognition index spatial learning spatial memory Spatial Memory staining Wistar rat
Online Access:	View Fulltext in Publisher View in Scopus

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