Synthesis and structure–activity relationship study of saponin-based membrane fusion inhibitors against SARS-CoV-2

Synthesis and structure–activity relationship study of saponin-based membrane fusion inhibitors against SARS-CoV-2

We previously discovered that triterpenoid saponin platycodin D inhibits the SARS-CoV-2 entry to the host cell. Herein, we synthesized various saponin derivatives and established a structure–activity relationship of saponin-based antiviral agents against SARS-CoV-2. We discovered that the C3-glucose...

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Bibliographic Details
Main Authors: Han, S. (Author), Jang, Y. (Author), Jeon, S. (Author), Justin Lee, C. (Author), Kim, S. (Author), Lee, J. (Author), Lim, H. (Author), Young Kim, T. (Author)
Format: Article
Language:English
Published: Academic Press Inc. 2022
Subjects:
Complex molecules synthesis
COVID-19
Membrane fusion
Saponins
SARS-CoV-2
Online Access:View Fulltext in Publisher

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