Platelet-Lymphocyte ratio is a predictor for the development of no-reflow phenomenon in patients with ST-segment elevation myocardial infarction after thrombus aspiration

• Main Authors: Emren, S.V (Author), Erseçgin, A. (Author), Gül, İ (Author), Şenöz, O. (Author), Yapan Emren, Z. (Author)
• Format: Article
• Language: English
• Published: John Wiley and Sons Inc 2021
• Subjects: adult; adverse event; Article; blood clot lysis; Blood Platelets; controlled study; disease course; female; Female; follow up; Follow-Up Studies; human; Humans; laboratory test; lymphocyte; Lymphocytes; major clinical study; male; Male; manual thrombus aspiration; mean corpuscular volume; middle aged; Middle Aged; no reflow; no reflow phenomenon; No-Reflow Phenomenon; pathogenesis; pathology; pathophysiology; percutaneous coronary intervention; Percutaneous Coronary Intervention; platelet lymphocyte ratio; platelet to lymphocyte ratio; population structure; postoperative period; prediction; predictive value; primary percutaneous coronary intervention; prognosis; Prognosis; Retrospective Studies; retrospective study; sensitivity and specificity; ST Elevation Myocardial Infarction; ST segment elevation myocardial infarction; ST-segment elevation myocardial infarction; suction; Suction; SYNTAX score; thrombocyte; thrombosis; Thrombosis; thrombus aspiration
• Online Access: View Fulltext in Publisher
• ISBN: 08878013 (ISSN)
• DOI: 10.1002/jcla.23795

Backround: We aimed to evaluate the utility of the preprocedural platelet–lymphocyte ratio (PLR) for predicting the no-reflow phenomenon after thrombus aspiration during percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI). Method: We retrospectively analyzed postprocedural thrombolysis in myocardial infarction (TIMI) flow grades and myocardial blush grades (MBG) of 247 patients who underwent a PCI procedure with thrombus aspiration.We divided these patients into two groups according to whether they had no-reflow (TIMI < 3, MBG < 2) or not (TIMI 3, MBG ≥ 2). Results: No-reflow developed in 43 (17%) patients.Preprocedural PLR was significantly higher in the no-reflow group (183.76 ± 56.65 vs 118.32 ± 50.42 p < 0.001).Independent predictors of no-reflow were as follows: higher preprocedural platelet-lymphocyte ratio (PLR) (OR = 1.018; 95% CI = 1.004, 1.033; p = 0.013),mean corpuscular volume (MCV) (OR = 1.118; 95% CI = 1.024, 1.220; p = 0.012) and SYNTAX Score-2 (OR = 1.073; 95% CI = 1.005, 1.146; p = 0.036). PLR of 144 had 79% sensitivity and 75% specificity for the prediction of no-reflow. Conclusion: PLR is a reliable predictor for no-reflow in STEMI patients undergoing thrombus aspiration. © 2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC