Association of ficolin-1 and ficolin-3 gene variation and pulmonary tuberculosis susceptibility in a Chinese population

• Main Authors: Li, H.-M (Author), Li, Y. (Author), Lin, W.-H (Author), Liu, X.-N (Author), Ma, D.-C (Author), Shen, D.-P (Author), You, E.-Q (Author), Zhang, X.-L (Author)
• Format: Article
• Language: English
• Published: John Wiley and Sons Inc 2021
• Subjects: adult; Adult; allele; Article; Asian continental ancestry group; Asian Continental Ancestry Group; case control study; Case-Control Studies; China; Chinese; clinical feature; cohort analysis; controlled study; drug induced liver damage; FCN1; FCN3; FCN3 protein, human; female; Female; fever; ficolin; ficolin 1 gene; ficolin 3 gene; gene; gene frequency; Gene Frequency; genetic association; Genetic Association Studies; genetic association study; genetic polymorphisms; genetic predisposition; Genetic Predisposition to Disease; genetic variation; genetics; genotype; haplotype; Haplotypes; human; Humans; hypoproteinemia; infection sensitivity; lectin; Lectins; leukopenia; liver injury; lung tuberculosis; major clinical study; male; Male; Polymorphism, Single Nucleotide; pulmonary tuberculosis; single nucleotide polymorphism; Tuberculosis, Pulmonary
• Online Access: View Fulltext in Publisher
• ISBN: 08878013 (ISSN)
• DOI: 10.1002/jcla.23732

Background: The aim of our study was to estimate the association of ficolin-1 (FCN1) gene (rs10120023, rs1071583) and ficolin-3 (FCN3) gene (rs3813800, rs10794501) polymorphisms and pulmonary tuberculosis (PTB) susceptibility, as well as their several clinical features, in a Chinese population. Methods: This study included a cohort of 489 PTB patients and 489 healthy controls, and the four SNPs were genotyped by improved multiple ligase detection reaction (iMLDR). Results: We found that there were no significant differences regarding the allele and genotype frequencies of FCN1 rs10120023, rs1071583 and FCN3 rs3813800, rs10794501 between PTB patients and healthy controls (all p > 0.05). The association of three main haplotypes (CC, CT, and TC) in FCN1 and three main haplotypes (CT, GA, and GT) in FCN3 with PTB susceptibility was also analyzed, and no significant association was detected (all p > 0.05). In FCN1, the rs1071583 TT genotype was significantly associated with the occurrence of drug resistance in PTB patients (p = 0.040). In addition, the GG genotype and G allele frequencies of rs3813800 in FCN3 gene were significantly higher in PTB patients with pulmonary infection (p = 0.027, p = 0.020, respectively). Conclusions: FCN1 and FCN3 genetic variation were not contributed to the pathogenesis of PTB in Chinese. While rs1071583 and rs3813800 variant might associate with several clinical characteristics of PTB. © 2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.