Metabolic syndrome in rheumatoid arthritis patients: Relationship among its clinical components

• Main Authors: Cerpa-Cruz, S. (Author), García-Chagollán, M. (Author), Hernández-Bello, J. (Author), Hernández-Martínez, S.E (Author), Lomelí-Nieto, J.A (Author), Macedo Ojeda, G. (Author), Morales-Núñez, J.J (Author), Muñoz-Valle, J.F (Author), Rojas-Romero, A.E (Author), Sigala-Arellano, R. (Author)
• Format: Article
• Language: English
• Published: John Wiley and Sons Inc 2021
• Subjects: adult; Adult; age; Arthritis, Rheumatoid; Article; blood; blood pressure measurement; body height; body weight; case control study; Case-Control Studies; Castelli's index; cholesterol; cholesterol blood level; Cholesterol, VLDL; complication; controlled study; DAS28; disease activity; disease association; female; Female; glucose; glucose blood level; high density lipoprotein cholesterol; human; Humans; joint swelling; lipid profiles; low density lipoprotein cholesterol; major clinical study; male; Male; metabolic syndrome; Metabolic Syndrome; metabolic syndrome X; Mexico; prevalence; Prevalence; rheumatoid arthritis; rheumatoid factor; smoking; triacylglycerol; triacylglycerol blood level; very low density lipoprotein cholesterol; waist circumference; Waist Circumference
• Online Access: View Fulltext in Publisher

 Background: Metabolic syndrome (MetS) prevalence in rheumatoid arthritis (RA) patients is known to vary considerably across the world. This study aimed to determine the prevalence of MetS in RA patients from western Mexico and to analyze the interrelation of the MetS components with the clinical variables of RA. Methods: This case-control study included 216 RA patients and 260 control subjects (CS). MetS prevalence was determined according to the NCEP/ATP III and the Latin American Consensus of the Latin American Diabetes Association (ALAD) criteria. Results: MetS was observed in 30.6% RA patients and 33.3% of controls (p > 0.05) according to NCEP/ATP III and 28.7% in RA patients and 31.1% for controls using ALAD criteria. Total cholesterol, LDL-C, and Castelli's I-II indexes were lower in RA (p < 0.001) than in CS. The RA patients with MetS had more swollen joints than those without MetS (p = 0.018). In RA patients with MetS, DAS-28 score correlated with smoking index (rho = 0.4601, p = 0.0004) and VLDL-C (rho = 0.3108, p = 0.0056); similarly, rheumatoid factor (RF) correlated with age (rho = 0.2031, p = 0.0027), smoking index (rho = 0.3404, p < 0.0001), triglycerides (rho = 0.1958, p = 0.0039), and VLDL-C (rho = 0.1761, p = 0.0162). Conclusions: The MetS prevalence in RA patients from western Mexico is not higher than controls; however, in RA patients with MetS, some inflammatory markers are associated with MetS components; thus, the control of MetS in RA could be beneficial to regulate disease activity. © 2020 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC