Diffusion tensor imaging brain structural clustering patterns in major depressive disorder

• Main Authors: Mann, J.J (Author), Miller, J.M (Author), Sublette, M.E (Author), Xu, D. (Author), Xu, G. (Author), Zhao, Z. (Author)
• Format: Article
• Language: English
• Published: John Wiley and Sons Inc 2021
• Subjects: adult; Adult; antidepressant agent; Article; Beck Depression Inventory; benzodiazepine derivative; brain; brain cortex; brain networking pattern; Cerebral Cortex; clinical article; controlled study; Depressive Disorder, Major; diagnostic imaging; diffusion tensor imaging; Diffusion Tensor Imaging; disease duration; disease exacerbation; Disease Progression; false discovery rate; female; Female; fractional anisotropy; Hamilton Depression Rating Scale; human; Humans; insula; left hemisphere; lingual gyrus; major depression; major depressive disorder; male; Male; middle aged; Middle Aged; nerve cell network; nerve cell plasticity; Nerve Net; neuroimaging; pathology; postcentral gyrus; primary motor cortex; psychopharmacotherapy; randomized controlled trial; right hemisphere; Structured Clinical Interview for DSM Disorders; suicidal ideation; time factor; Time Factors; tractography
• Online Access: View Fulltext in Publisher

 Using magnetic resonance diffusion tensor imaging data from 45 patients with major depressive disorder (MDD) and 41 healthy controls (HCs), network indices based on a 246-region Brainnetcome Atlas were investigated in the two groups, and in the MDD subgroups that were subgrouped based on their duration of the disease. Correlation between the network indices and the duration of illness was also examined. Differences were observed between the MDDS subgroup (short disease duration) and the HC group, but not between the MDD and HC groups. Compared with the HCs, the clustering coefficient (CC) values of MDDS were higher in precentral gyrus, and caudal lingual gyrus; the CC of MDDL subgroup (long disease duration) was higher in postcentral gyrus and dorsal granular insula in the right hemisphere. Network resilience analyses showed that the MDDS group was higher than the HC group, representing relatively more randomized networks in the diseased brains. The correlation analyses showed that the caudal lingual gyrus in the right hemisphere and the rostral lingual gyrus in the left hemisphere were particularly correlated with disease duration. The analyses showed that duration of the illness appears to have an impact on the networking patterns. Networking abnormalities in MDD patients could be blurred or hidden by the heterogeneity of the MDD clinical subgroups. Brain plasticity may introduce a recovery effect to the abnormal network patterns seen in patients with a relative short term of the illness, as the abnormalities may disappear in MDDL. © 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.