Longitudinal changes in regional cerebral blood flow in late middle-aged and older adults with treated and untreated obstructive sleep apnea

• Main Authors: Baril, A.-A (Author), Gagnon, K. (Author), Gosselin, N. (Author), Lafond, C. (Author), L'Heureux, F. (Author), Montplaisir, J. (Author), Soucy, J.-P (Author)
• Format: Article
• Language: English
• Published: John Wiley and Sons Inc 2021
• Subjects: adult; aged; Aged; aging; Article; brain blood flow; brain circulation; Cerebrovascular Circulation; clinical article; continuous positive airway pressure; Continuous Positive Airway Pressure; controlled study; diagnostic imaging; female; Female; hexamethylpropylene amine oxime technetium tc 99m; hippocampus; Hippocampus; human; Humans; left hippocampus; Longitudinal Studies; longitudinal study; male; Male; middle aged; Middle Aged; neuroimaging; obstructive sleep apnea; Outcome Assessment, Health Care; parahippocampal gyrus; Parahippocampal Gyrus; pathophysiology; physiology; polysomnography; Polysomnography; positive end expiratory pressure ventilation; regional cerebral blood flow; single photon emission computed tomography; Sleep Apnea, Obstructive; sleep disordered breathing; Tomography, Emission-Computed, Single-Photon
• Online Access: View Fulltext in Publisher
• ISBN: 10659471 (ISSN)
• DOI: 10.1002/hbm.25443

Obstructive sleep apnea (OSA) is associated with abnormal cerebral perfusion at wakefulness, but whether these anomalies evolve over time is unknown. Here, we examined longitudinal changes in regional cerebral blood flow (rCBF) distribution in late middle-aged and older adults with treated or untreated OSA. Twelve controls (64.8 ± 8.0 years) and 23 participants with newly diagnosed OSA (67.8 ± 6.2 years) were evaluated with polysomnography and cerebral 99mTc-HMPAO single-photon emission computed tomography during wakeful rest. OSA participants were referred to a sleep apnea clinic and 13 of them decided to start continuous positive airway pressure (CPAP). Participants were tested again after 18 months. Voxel-based analysis and extracted relative rCBF values were used to assess longitudinal changes. Untreated OSA participants showed decreased relative rCBF in the left hippocampus and the right parahippocampal gyrus over time, while treated participants showed trends for increased relative rCBF in the left hippocampus and the right parahippocampal gyrus. No changes were found over time in controls. Untreated OSA is associated with worsening relative rCBF in specific brain areas over time, while treated OSA shows the opposite. Considering that OSA possibly accelerates cognitive decline in older adults, CPAP treatment could help reduce risk for cognitive impairment. © 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.