Optimizing Lipid Nanoparticles for Delivery in Primates

Optimizing Lipid Nanoparticles for Delivery in Primates

Lipid nanoparticles (LNPs) are clinically proven to successfully deliver both small interfering RNA (siRNA) therapeutics and larger mRNA payloads for prophylactic vaccine applications. Non-human primates (NHPs) are generally considered to be the most predictive of human responses. However, for ethic...

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Bibliographic Details
Main Authors: Heyes, J. (Author), Lam, K. (Author), Leung, A. (Author), Lutwyche, P. (Author), Reid, S. (Author), Schreiner, P. (Author), Stainton, P. (Author), Yaworski, E. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2023
Subjects:
Controlled drug delivery
Human response
lipid nanoparticles
Lipid nanoparticles
Mammals
Messenger RNA
Nanoparticles
nanotechnology
Non-human primate
nucleic acid
particle size
Particle size
Particles sizes
PEG shielding
Polyethylene glycols
potency translation
Potency translation
Product design
RNA
RNA therapeutics
Small interfering RNA
Surface chemistry
Targeted drug delivery
Therapeutic
therapeutics
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