2-Pyridine Carboxaldehyde for Semi-Automated Soft Spot Identification in Cyclic Peptides

2-Pyridine Carboxaldehyde for Semi-Automated Soft Spot Identification in Cyclic Peptides

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Cyclic peptides are an attractive option as therapeutics due to their ability to disrupt crucial protein–protein interactions and their flexibility in display type screening strategies, but they come with their own bioanalytical challenges in metabolite identification. Initial amide hydrolysis of a...

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Bibliographic Details
Main Authors: Cannon, J.R (Author), Chacko, S. (Author), Zhang, H. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
macrocyclic peptide
peptide
proteolysis
proteolytic stability
site-specific conjugation
soft spot
Online Access:View Fulltext in Publisher

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