Magnetic Hyperthermia Nanoarchitectonics via Iron Oxide Nanoparticles Stabilised by Oleic Acid: Anti-Tumour Efficiency and Safety Evaluation in Animals with Transplanted Carcinoma

• Main Authors: Ageev, V.P (Author), Balykova, L.A (Author), Inchina, V.I (Author), Kulikov, O.A (Author), Pyataev, N.A (Author), Shlyapkina, V.I (Author), Sukhorukov, G.B (Author), Tishin, A.M (Author), Yakobson, D.E (Author), Zaborovskiy, A.V (Author), Zharkov, M.N (Author)
• Format: Article
• Language: English
• Published: MDPI 2022
• Subjects: anti-tumour activity; iron oxide nanoparticles; magnetic hyperthermia; oleic acid; toxicity; W256 carcinoma
• Online Access: View Fulltext in Publisher
• ISBN: 16616596 (ISSN)
• DOI: 10.3390/ijms23084234

In this study, we developed iron oxide nanoparticles stabilised with oleic acid/sodium oleate that could exert therapeutic effects for curing tumours via magnetic hyperthermia. A suspension of iron oxide nanoparticles was produced and characterised. The toxicity of the synthesised composition was examined in vivo and found to be negligible. Histological examination showed a low local irritant effect and no effect on the morphology of the internal organs. The efficiency of magnetic hyperthermia for the treatment of transplanted Walker 256 carcinoma was evaluated. The tumour was infiltrated with the synthesised particles and then treated with an alternating magnetic field. The survival rate was 85% in the studied therapy group of seven animals, while in the control group (without treatment), all animals died. The physicochemical and pharmaceutical properties of the synthesised fluid and the therapeutic results, as seen in the in vivo experiments, provide insights into therapeutic hyperthermia using injected magnetite nanoparticles. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.