Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells

Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells

Studies of monogenic diabetes are particularly useful because we can gain insight into the molecular events of pancreatic β-cell failure. Maturity-onset diabetes of the young 1 (MODY1) is a form of monogenic diabetes caused by a mutation in the HNF4A gene. Human-induced pluripotent stem cells (hiPSC...

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Main Authors: Abadpour, S. (Author), Bjørlykke, Y. (Author), Carrasco, M. (Author), Chera, S. (Author), Ghabayen, J. (Author), Ghila, L.M (Author), Lyssenko, V. (Author), Nermoen, I. (Author), Njølstad, P. (Author), Paulo, J.A (Author), Ræder, H. (Author), Scholz, H. (Author), Søviknes, A.M (Author), Tjora, E. (Author), Vaudel, M. (Author), Wang, C. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
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