Flap endonuclease 1 and DNA-PKcs synergistically participate in stabilizing replication fork to encounter replication stress in glioma cells

Flap endonuclease 1 and DNA-PKcs synergistically participate in stabilizing replication fork to encounter replication stress in glioma cells

Background: Selectively utilizing alternative mechanisms to repair damaged DNA in essential factors deficient cancer facilitates tumor genetic evolution and contributes to treatment resistance. Synthetic lethality strategies provide a novel scenario to anticancer therapy with DNA repair protein muta...

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Bibliographic Details
Main Authors: Chen, M. (Author), Cheng, M. (Author), Huang, B. (Author), Lian, H. (Author), Liu, M. (Author), Pang, Y. (Author), Xu, S. (Author), Zhang, J. (Author), Zhong, C. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
DNA damage
DNA replication
Genome instability
Glioma
Synthetic lethality
Tumor genetic evolution
Online Access:View Fulltext in Publisher

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