Connective tissue growth factor mediates bone morphogenetic protein 2-induced increase in hyaluronan production in luteinized human granulosa cells

Connective tissue growth factor mediates bone morphogenetic protein 2-induced increase in hyaluronan production in luteinized human granulosa cells

Background: Hyaluronan is the main component of the cumulus-oocyte complex (COC) matrix, and it maintains the basic structure of the COC during ovulation. As a member of the transforming growth factor β (TGF-β) superfamily, bone morphogenetic protein 2 (BMP2) has been identified as a critical regula...

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Bibliographic Details
Main Authors: Bai, L. (Author), Chang, H.-M (Author), Leung, P.C.K (Author), Zhu, Y.-M (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
BMP2
CTGF
HAS2
Human granulosa cells
Hyaluronan
Online Access:View Fulltext in Publisher

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