Migraine susceptibility is modulated by food triggers and analgesic overuse via sulfotransferase inhibition

Migraine susceptibility is modulated by food triggers and analgesic overuse via sulfotransferase inhibition

Background/aim: Certain constituents in migraine food triggers and non-steroidal anti-inflammatory drugs (NSAIDs) inhibit sulfotransferases (SULTs) that detoxify drugs/chemicals and play role in the metabolism of neurotransmitters. We aimed to dissect SULT1A1 modulation of CSD susceptibility and beh...

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Bibliographic Details
Main Authors: Arslan, B. (Author), Ayata, C. (Author), Bolay, H. (Author), de Morais, A.L (Author), Gulbahar, O. (Author), Topa, E. (Author), Vuralli, D. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
adult
animal
animal experiment
animal model
animal tissue
Animals
Anti-Inflammatory Agents, Non-Steroidal
Article
behavior change
citrus fruit
controlled study
Cortical spreading depression
disease predisposition
disease simulation
drug exposure
elevated plus maze test
enzyme activity
enzyme inhibition
food
grooming
head movement
hesperidin
human
Humans
hypersensitivity
in vivo study
locomotion
male
medication overuse
Medication overuse
mefenamic acid
Mefenamic Acid
metabolism
migraine
Migraine Disorders
Migraine food triggers
nonhuman
nonsteroid antiinflammatory agent
Prescription Drug Overuse
provocation
rat
Rats
spreading cortical depression
sulfotransferase
sulfotransferase 1A1
Sulfotransferases
SULT1A1
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