Time of Day of Vaccination Affects SARS-CoV-2 Antibody Responses in an Observational Study of Health Care Workers

The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global crisis with unprecedented challenges for public health. Vaccinations against SARS-CoV-2 have slowed the incidence of new infections and reduced disease severity. As the time of day of vaccination...

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Bibliographic Details
Main Authors: Balfe, P. (Author), Crook, D.W (Author), Eyre, D.W (Author), Jeffery, K. (Author), Klerman, E.B (Author), Lumley, S.F (Author), Matthews, P.C (Author), McKeating, J.A (Author), O’Donnell, D. (Author), Wang, W. (Author), Warren, F. (Author)
Format: Article
Language:English
Published: SAGE Publications Inc. 2022
Subjects:
HCW
Online Access:View Fulltext in Publisher
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245 1 0 |a Time of Day of Vaccination Affects SARS-CoV-2 Antibody Responses in an Observational Study of Health Care Workers 
260 0 |b SAGE Publications Inc.  |c 2022 
300 |a 6 
856 |z View Fulltext in Publisher  |u https://doi.org/10.1177/07487304211059315 
520 3 |a The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global crisis with unprecedented challenges for public health. Vaccinations against SARS-CoV-2 have slowed the incidence of new infections and reduced disease severity. As the time of day of vaccination has been reported to influence host immune responses to multiple pathogens, we quantified the influence of SARS-CoV-2 vaccination time, vaccine type, participant age, sex, and days post-vaccination on anti-Spike antibody responses in health care workers. The magnitude of the anti-Spike antibody response is associated with the time of day of vaccination, vaccine type, participant age, sex, and days post-vaccination. These results may be relevant for optimising SARS-CoV-2 vaccine efficacy. © 2021 The Author(s). 
650 0 4 |a Antibody Formation 
650 0 4 |a antibody production 
650 0 4 |a circadian rhythm 
650 0 4 |a Circadian Rhythm 
650 0 4 |a COVID-19 
650 0 4 |a COVID-19 
650 0 4 |a COVID-19 Vaccines 
650 0 4 |a HCW 
650 0 4 |a health care personnel 
650 0 4 |a Health Personnel 
650 0 4 |a human 
650 0 4 |a Humans 
650 0 4 |a pandemic 
650 0 4 |a Pandemics 
650 0 4 |a SARS-CoV-2 
650 0 4 |a SARS-CoV-2 
650 0 4 |a Spike antibody 
650 0 4 |a time of day 
650 0 4 |a vaccination 
650 0 4 |a Vaccination 
700 1 0 |a Balfe, P.  |e author 
700 1 0 |a Crook, D.W.  |e author 
700 1 0 |a Eyre, D.W.  |e author 
700 1 0 |a Jeffery, K.  |e author 
700 1 0 |a Klerman, E.B.  |e author 
700 1 0 |a Lumley, S.F.  |e author 
700 1 0 |a Matthews, P.C.  |e author 
700 1 0 |a McKeating, J.A.  |e author 
700 1 0 |a O’Donnell, D.  |e author 
700 1 0 |a Wang, W.  |e author 
700 1 0 |a Warren, F.  |e author 
773 |t Journal of Biological Rhythms