Time of Day of Vaccination Affects SARS-CoV-2 Antibody Responses in an Observational Study of Health Care Workers

• Main Authors: Balfe, P. (Author), Crook, D.W (Author), Eyre, D.W (Author), Jeffery, K. (Author), Klerman, E.B (Author), Lumley, S.F (Author), Matthews, P.C (Author), McKeating, J.A (Author), O’Donnell, D. (Author), Wang, W. (Author), Warren, F. (Author)
• Format: Article
• Language: English
• Published: SAGE Publications Inc. 2022
• Subjects: Antibody Formation; antibody production; circadian rhythm; Circadian Rhythm; COVID-19; COVID-19 Vaccines; HCW; health care personnel; Health Personnel; human; Humans; pandemic; Pandemics; SARS-CoV-2; Spike antibody; time of day; vaccination; Vaccination
• Online Access: View Fulltext in Publisher
• Physical Description: 6
• ISBN: 07487304 (ISSN)
• DOI: 10.1177/07487304211059315

The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global crisis with unprecedented challenges for public health. Vaccinations against SARS-CoV-2 have slowed the incidence of new infections and reduced disease severity. As the time of day of vaccination has been reported to influence host immune responses to multiple pathogens, we quantified the influence of SARS-CoV-2 vaccination time, vaccine type, participant age, sex, and days post-vaccination on anti-Spike antibody responses in health care workers. The magnitude of the anti-Spike antibody response is associated with the time of day of vaccination, vaccine type, participant age, sex, and days post-vaccination. These results may be relevant for optimising SARS-CoV-2 vaccine efficacy. © 2021 The Author(s).