Triglyceride-derived fatty acids reduce autophagy in a model of retinal angiomatous proliferation

Triglyceride-derived fatty acids reduce autophagy in a model of retinal angiomatous proliferation

Dyslipidemia and autophagy have been implicated in the pathogenesis of blinding neovascular age-related macular degeneration (NV-AMD). VLDL receptor (VLDLR), expressed in photoreceptors with a high metabolic rate, facilitates the uptake of triglyceride-derived fatty acids. Since fatty acid uptake is...

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Main Authors: Agnihotri, T. (Author), Andelfinger, G. (Author), Cagnone, G. (Author), Cakir, B. (Author), Chemtob, S. (Author), Clish, C.B (Author), Das, A. (Author), Dennis, C. (Author), Heckel, E. (Author), Joyal, J.-S (Author), Kim, J.S (Author), Kim, N. (Author), Lavoie, G. (Author), Mitchell, G.A (Author), Pierce, K.A (Author), Pundir, S. (Author), Rezende, F.A (Author), Roux, P.P (Author), Sapieha, P. (Author), Situ, A. (Author), Smith, L.E.H (Author), Sun, Y. (Author), Wünnemann, F. (Author)
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022
Online Access:View Fulltext in Publisher

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