Protecting effect of emodin in experimental autoimmune encephalomyelitis mice by inhibiting microglia activation and inflammation via Myd88/PI3K/Akt/NF-κB signalling pathway

Protecting effect of emodin in experimental autoimmune encephalomyelitis mice by inhibiting microglia activation and inflammation via Myd88/PI3K/Akt/NF-κB signalling pathway

Experimental autoimmune encephalomyelitis (EAE) is characterized by demyelination of the central nervous system. Emodin is an anthraquinone derivative with comprehensive anti-inflammatory, anti-cancer, and immunomodulatory effects and is widely used in the treatment of inflammatory, tumor, and immun...

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Bibliographic Details
Main Authors:	Li, X. (Author), Lv, B. (Author), Wang, C. (Author), Wu, L. (Author), Wu, Z. (Author), Xu, H. (Author), Zhao, Y. (Author), Zheng, K. (Author), Zheng, Z. (Author)
Format:	Article
Language:	English
Published:	Taylor and Francis Ltd. 2022
Subjects:	animal Animals antiinflammatory agent Anti-Inflammatory Agents C57BL mouse emodin Emodin Encephalomyelitis, Autoimmune, Experimental experimental autoimmune encephalomyelitis immunoglobulin enhancer binding protein inflammation Inflammation metabolism Mice Mice, Inbred C57BL microglia Microglia microglia activation molecular docking Molecular Docking Simulation mouse MS/EAE Myd88 protein, mouse myelin protective myeloid differentiation factor 88 Myeloid Differentiation Factor 88 network pharmacology NF-kappa B pathology phosphatidylinositol 3 kinase Phosphatidylinositol 3-Kinases PI3K/AKT/NF- κB signalling pathway protein kinase B Proto-Oncogene Proteins c-akt spinal cord Spinal Cord TLRs/MyD88 signal
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