HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells

HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells

HIV-1 replicates in CD4+ T cells, leading to AIDS. Determining how HIV-1 shapes its niche to create a permissive environment is central to informing efforts to limit pathogenesis, disturb reservoirs, and achieve a cure. A key roadblock in understanding HIV-T cell interactions is the requirement to a...

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Bibliographic Details
Main Authors: Dullabh, K.J (Author), Fidler, S. (Author), Guerra-Assunção, J.A (Author), Herrera, C. (Author), Jolly, C. (Author), Madansein, R. (Author), Maini, M.K (Author), Mesner, D. (Author), Noursadeghi, M. (Author), Pallett, L.J (Author), Reuschl, A.-K (Author), Shivkumar, M. (Author), Sigal, A. (Author), Thornhill, J.P (Author), Whelan, M.V.X (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2022
Subjects:
cell-cell
CP: Immunology
CP: Microbiology
HIV-1
permissivity
resting memory T cell
tissue residency
transcriptional reprogramming
Vpr
Online Access:View Fulltext in Publisher

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