Single-Cell Transcriptomics Reveal Disrupted Kidney Filter Cell-Cell Interactions after Early and Selective Podocyte Injury

Single-Cell Transcriptomics Reveal Disrupted Kidney Filter Cell-Cell Interactions after Early and Selective Podocyte Injury

The health of the kidney filtration barrier requires communication among podocytes, endothelial cells, and mesangial cells. Disruption of these cell-cell interactions is thought to contribute to disease progression in chronic kidney diseases (CKDs). Podocyte ablation via doxycycline-inducible deleti...

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Bibliographic Details
Main Authors:	Chen, F. (Author), Chen, H. (Author), Clark, A.R (Author), Greka, A. (Author), Marshall, J. (Author), Montesinos, M.S (Author), Nguyen, L. (Author), Zhou, Y. (Author)
Format:	Article
Language:	English
Published:	Elsevier Inc. 2022
Subjects:	animal animal cell Animals Article cell communication Cell Communication cell damage cell interaction cell population cell survival chronic kidney failure collagen type 4 controlled study cytoskeleton female genetics glomerulus filtration integrin knockout mouse male mesangium cell metabolism Mice Mice, Knockout mitochondrion mouse nonhuman pathology podocyte Podocytes protein expression Renal Insufficiency, Chronic RNA sequencing signal transduction single cell analysis Single-Cell Analysis transcriptome Transcriptome transcriptomics upregulation
Online Access:	View Fulltext in Publisher

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