Cathepsin K activity controls cachexia-induced muscle atrophy via the modulation of IRS1 ubiquitination

Cathepsin K activity controls cachexia-induced muscle atrophy via the modulation of IRS1 ubiquitination

Background: Cachexia is a complicated metabolic disorder that is characterize by progressive atrophy of skeletal muscle. Cathepsin K (CTSK) is a widely expressed cysteine protease that has garnered attention because of its enzymatic and non-enzymatic functions in signalling in various pathological c...

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Bibliographic Details
Main Authors: Cheng, X.W (Author), Huang, Z. (Author), Inoue, A. (Author), Jin, X. (Author), Kuzuya, M. (Author), Meng, X. (Author), Shi, G.-P (Author), Wan, Y. (Author), Wang, H. (Author), Xu, S. (Author), Yue, X. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2022
Subjects:
Cachexia
Cathepsin K
Insulin receptor substrate 1
Muscle wasting
Ubiquitination
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