Chapter 11 Metabolomics in the Analysis of Inflammatory Diseases

• Main Author: Clay, Elizabeth (auth)
• Other Authors: Kapoor, Sabrina (auth), Bayley, Rachel (auth), Wallace, Graham R. (auth), Young, Stephen P. (auth), Fitzpatrick, Martin (auth), R., Graham (auth), P., Stephen (auth)
• Format: eBook
• Published: InTechOpen 2012
• Subjects: Biochemistry; molecular biology; biochemistry; genetics; Hypoxia (medical); Inflammation; Lactic acid; Metabolism; Metabolite; Metabolomics; Rheumatoid arthritis
• Online Access: Get fulltext
• ISBN: 31814
• Access: Open Access

Most infections and traumatic injuries are cleared or repaired relatively rapidly and metabolic homoeostasis is soon restored. However, there is a broad range of inflammatory diseases which involve chronic activation of the immune system and, as a result, chronic persistent inflammation. We have been studying the metabolic consequences of chronic inflammatory diseases with the aim of identifying metabolic fingerprints which may provide clues about why the localised tissue disease persists.