Increased Circulatory Lipopolysaccharide From a High Fat Diet Aggravates Inflammation and Exacerbates Renal Failure

• Main Author: Righi, Samuel
• Format: Others
• Published: VCU Scholars Compass 2014
• Subjects: Renal Failure; Lipopolysaccharide; High Fat Diet; Inflammation; Chronic Kidney Disease; Renal Insufficiency; CKD; LPS; Life Sciences; Physiology
• Online Access: http://scholarscompass.vcu.edu/etd/3444; http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=4443&context=etd

Kidney failure is frequently associated with the risk factors linked to metabolic syndrome. Lipopolysaccharide (LPS) is a potent inflammatory molecule, which has increased absorption from the gut into blood circulation following a high fat and high-energy diet. We hypothesized that LPS from a high fat diet can amplify inflammation, thereby exacerbating chronic kidney disease and associated disorders. We have found that adding a high fat diet to renal insufficient mice significantly progressed their kidney disease as well as associated disorders, compared to both a high fat diet and renal insufficiency alone. Additionally, we were able to demonstrate in vitro that the combination of LPS and palmitic acid, a marker of high fat diet, induced inflammatory pathways significantly more than either LPS or palmitic acid alone. These results provide insight into connection between a high fat diet and the progression of chronic kidney disease as well as associated disorders.