PREDICTION OF HUMAN SYSTEMIC, BIOLOGICALLY RELEVANT
PHARMACOKINETIC PROPERTIES BASED ON PHYSICOCHEMICAL PROPERTIES OF CALCIUM CHANNEL BLOCKERS

PREDICTION OF HUMAN SYSTEMIC, BIOLOGICALLY RELEVANT PHARMACOKINETIC PROPERTIES BASED ON PHYSICOCHEMICAL PROPERTIES OF CALCIUM CHANNEL BLOCKERS

This research explored quantitative relationships (QSPKR) between different molecular descriptors and pertinent, systemic PK properties for 14 calcium channel blockers (CCB). Physicochemical properties (PC) such as molecular weight (MW), molar volume (MV), calculated logP (clogP), pKa, calculated lo...

Full description

Bibliographic Details
Main Author:	Al, Tafif Abdullah
Format:	Others
Published:	VCU Scholars Compass 2012
Subjects:	QSPKR CCB pharmacokinetics Medicine and Health Sciences Pharmacy and Pharmaceutical Sciences
Online Access:	http://scholarscompass.vcu.edu/etd/2868 http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=3867&context=etd

Similar Items

PREDICTION OF HUMAN SYSTEMIC, BIOLOGICALLY RELEVANT PHARMACOKINETIC (PK) PROPERTIES USING QUANTITATIVE STRUCTURE PHARMACOKINETIC RELATIONSHIPS (QSPKR) AND INTERSPECIES PHARMACOKINETIC ALLOMETRIC SCALING (PK-AS) APPROACHES FOR FOUR DIFFERENT PHARMACOLOGICAL CLASSES OF COMPOUNDS
by: Gottipati, Gopichand
Published: (2014)

PREDICTION OF HUMAN SYSTEMIC, BIOLOGICALLY RELEVANT PHARMACOKINETIC (PK) PROPERTIES BASED ON QUANTITATIVE STRUCTURE PHARMACOKINETIC RELATIONSHIPS (QSPKR) AND INTERSPECIES PHARMACOKINETIC ALLOMETRIC SCALING (PK-AS)
by: Badri, Prajakta
Published: (2010)

Population pharmacokinetics of ethanol and delta-9 tetrahydrocannabinol in human subjects
by: Jiang, Yu
Published: (2017)

Population pharmacokinetics of pyronaridine in the treatment of malaria
by: Wattanavijitkul, Thitima
Published: (2010)

Physiologically based pharmacokinetic (PBPK) model of Ivermectin (IVM)
by: Alsmadi, Mo'tasem Mohamed
Published: (2014)

Population pharmacokinetics and pharmacodynamics of pyronaridine
by: Methaneethorn, Janthima
Published: (2013)

The relative predictive performance of three pharmacokinetic programs for aminoglycosides dosing
by: Chang, Jen-Chieh Jason
Published: (1997)

Physicochemical properties of opiates : analytical and biological relevance
by: Knaggs, Roger D.
Published: (1997)

Evaluation of 10-fold cross validation and prediction error sums of squares statistic for population pharmacokinetic model validation
by: Harite, Shibani
Published: (2003)

Laporan kasus berbasis bukti: Efektifitas Pemberian Calcium Channel Blocker pada Perdarahan Subaraknoid Akibat Trauma Kepala
by: Irawan Mangunatmadja, et al.
Published: (2020-12-01)

Establishing a Pharmacokinetic Profile of Methylphenidate Use in Pregnancy: A Study in Mice
by: Peters, Haley T., et al.
Published: (2016)

Evaluation of bootstrapping as a validation technique for population pharmacokinetic models
by: Al-otoum, Mohammed Fawzi
Published: (2004)

Calcium channel blocker-induced gingival overgrowth
by: Ellis, Janice
Published: (1997)

Population pharmacokinetics of artesunate and dihydroartemisinin in children and pregnant women with malaria
by: Morris, Carrie Ann
Published: (2014)

Pharmacokinetic modeling of vancomycin in children, pre-adolescent, and adolescent patients : development, assessment, and application
by: Asiri, Yousif Abdu
Published: (1998)

Population pharmacokinetics of artesunate and its active metabolite dihydroartemisinin
by: Tan, Bee San
Published: (2009)

Population pharmacokinetics of telapristone and its active metabolite CDB-4453
by: Morris, Denise Nichole
Published: (2011)

Comparative effect of angiotensin II type I receptor blockers and calcium channel blockers on laboratory parameters in hypertensive patients with type 2 diabetes
by: Nishida Yayoi, et al.
Published: (2012-05-01)

Pharmacokinetics of pyronaridine in adult and pediatric populations
by: Ayyoub, Amal Suleiman
Published: (2016)

PHARMACOKINETICS OF SYNTHETIC CATHINONES FOUND IN "BATH SALTS" IN MOUSE BRAIN AND PLASMA USING LIQUID CHROMATOGRAPHY - MASS SPECTROMETRY
by: Schreiner, Shannon CA, et al.
Published: (2018)

Evaluation of Analytical, Pharmacokinetic and Pharmacodynamic Methods for the Study of Digoxin
by: Vetticaden, Santosh John
Published: (1985)

Effect of rutaecarpine on caffeine pharmacokinetics in rats
by: Estari, Rohit Kumar
Published: (2015)

Clinical and genetic determinants of tacrolimus pharmacokinetics and pharmacodynamics in the transplant population
by: Kirresh, Tatian
Published: (2014)

Exploring the Use of Computer-aided Learning Modules (CAL) to Enhance the Teaching and Learning of Pharmacokinetics to Pharmacy Students
by: Hussain, M, et al.
Published: (2020)

A pharmacokinetic receptor-based recirculation model for target-mediated disposition drugs
by: El-Komy, Mohammed Hassan Mohammed Ewis
Published: (2012)

DEVELOPMENT AND VALIDATION OF A SEMI-PHYSIOLOGICAL PHARMACOKINETIC (PBPK) MODEL TO PREDICT SYSTEMIC AND PULMONARY EXPOSURES AFTER INTRAVENOUS, ORAL ADMINISTRATION AND PULMONARY INHALATION OF SELECTED DRUGS, BUDESONIDE, TOBRAMYCIN AND CIPROFLOXACIN, IN HUMANS
by: Hanna, Bishoy
Published: (2018)

THE PHARMACOKINETICS OF METAL-BASED ENGINEERED NANOMATERIALS, FOCUSING ON THE BLOOD-BRAIN BARRIER
by: Dan, Mo
Published: (2013)

Risk assessment for drug degradation products using physiologically-based pharmacokinetic models
by: Nguyen, Quynh Hoa
Published: (2014)

A possible role for abscisic acid analogues as calcium channel blockers in mammalian smooth muscle
by: Lynch, Mark
Published: (1991)

Alternative Pharmacokinetic Models in End Stage Renal Disease During Continuous Ambulatory Peritoneal Dialysis
by: Cefali, Eugenio
Published: (1987)

Evaluation of the Pharmacokinetic-Pharmacodynamic relationship, Metabolism and Plasma Protein Binding of the novel antitumor agent, 2-Methoxyestradiol (2ME2), following oral administration in patients with solid tumors.
by: Lakhani, Nehal Jagdish
Published: (2005)

Investigation Of Physicochemical And Formulation Parameters For Transdermal Delivery Of Isoproterenol HC1
by: Patel, Rajesh Arvindkumar
Published: (1987)

Pharmacokinetics and Pharmacodynamics of Ethanol in Healthy Volunteers: Effects of Input-Rate and Degree of Ethanol Exposure on Subjective and Objective Measures of Impairment
by: Ramchandani, Vijay A.
Published: (1996)

Size and surface properties determining nanoparticle uptake and transport in the nasal mucosa
by: Chen, Nan
Published: (2013)

Beta-Blockers Act through Clathrin-Dependent Internalization and EGFR Transactivation to Promote ERK Phosphorylation
by: Ajumobi, Taiwo
Published: (2014)

Role of Polymer Physicochemical Properties on in vitro Mucoadhesion
by: Zhang, Qing
Published: (2020)

Protein reactivity of 3,4-dihydroxyphenylacetaldehyde, an endogenous, potential neurotoxin relevant to Parkinson's disease
by: Rees, Jennifer Nicole
Published: (2009)

THE IMPACT OF CYP3A4*22 AND CYP3A5*3 ON DEXAMETHASONE AND 6-HYDROXY-DEXAMETHASONE PHARMACOKINETICS IN PHASE 1/2 CANCER PATIENTS
by: He, Lei
Published: (2013)

An examination of the effect of surface modifications on the physicochemical and biological properties of non-ionic surfactant vesicles
by: Cable, Colin
Published: (1990)

Adenosine 3', 5'-cyclic monophosphate activation of islet chloride channels
by: Varandani, Anjali
Published: (1998)