Involvement of p53 in the S-phase Checkpoint during Nucleotide Deficiencies
Several classes of antimetabolites have been developed for the treatment of cancer, including numerous inhibitors of nucleotide biosynthesis. N-(phosphonacetyl)-L-aspartate (PALA) and hydroxyurea (HU) are two antimetabolites that inhibit nucleotide biosynthesis; PALA inhibits de novo pyrimidine syn...
| Main Author: | |
|---|---|
| Format: | Others |
| Published: |
VCU Scholars Compass
2011
|
| Subjects: | |
| Online Access: | http://scholarscompass.vcu.edu/etd/2439 http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=3438&context=etd |