THE PROGNOSTIC POTENTIAL OF THE EPIDERMAL GROWTH FACTOR RECEPTOR AND NUCLEAR FACTOR KAPPA B PATHWAYS AND ASSOCIATED THERAPEUTIC STRATEGIES IN PATIENTS WITH SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK

THE PROGNOSTIC POTENTIAL OF THE EPIDERMAL GROWTH FACTOR RECEPTOR AND NUCLEAR FACTOR KAPPA B PATHWAYS AND ASSOCIATED THERAPEUTIC STRATEGIES IN PATIENTS WITH SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK

Little is known about the signaling pathways that contribute to treatment response in advanced stage head and neck tumors. Increased expression of epidermal growth factor receptor (EGFR) and downstream pathways such as nuclear factor kappa B (NFκB) are implicated in aggressive tumor phenotypes and l...

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Bibliographic Details
Main Author:	Wirth, Pamela
Format:	Others
Published:	VCU Scholars Compass 2010
Subjects:	head and neck squamous cell carcinoma gefitinib bortezomib epidermal growth factor receptor nuclear factor kappa B MTS Assay Ingenuity Pathway Analysis Western blot polymerase chain reaction DNA binding assay Medicine and Health Sciences
Online Access:	http://scholarscompass.vcu.edu/etd/2229 http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=3228&context=etd

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