ROLE OF BCL-2 FAMILY MEMBERS TO PROMOTE GLUCOCORTICOID –INDUCED APOPTOSIS BY MEK INHIBITORS IN LEUKEMIC CELLS
Glucocorticoids (GC) are common components of many chemotherapeutic regimens for lymphoid malignancies. GC-induced apoptosis involves an intrinsic BCL-2 family-regulated pathway. It has been shown that BIM (BCL-2 interacting mediator of cell death), a BH3-only pro-apoptotic protein, is up-regulate...
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VCU Scholars Compass
2009
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| Online Access: | http://scholarscompass.vcu.edu/etd/1790 http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=2789&context=etd |