Prediction of In-Vivo Antimuscarinic Activity (AMA) by In-Vitro Receptor Binding Assessment and PK/PD Modeling For Prototypical Drugs
Purpose: To establish a tool, termed as antimuscarinic activity (AMA), to predict the incidence of antimuscarinic adverse events (AMAEs).Methods: A literature review, focused on drugs having off-target interaction with muscarinic receptors, was performed. Prototypical drugs olanzapine, diphenhydrami...
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VCU Scholars Compass
2007
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| Online Access: | http://scholarscompass.vcu.edu/etd/1348 http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=2347&context=etd |