Type-5 Phosphodiesterase Inhibition in the Prevention of Doxorubicin Cardiomyopathy
Prior studies have demonstrated the effect of diazoxide in protecting against apoptosis via mitochondrial KATP channel opening in vitro. The current investigations are designed to determine if sildenafil, a phosphodiesterase-5 inhibitor and known mitochondrial KATP channel opener, would protect aga...
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| Format: | Others |
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VCU Scholars Compass
2005
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| Online Access: | http://scholarscompass.vcu.edu/etd/1162 http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=2161&context=etd |