Characterization Of A Non-Canonical Function For Threonyl-Trna Synthetase In Angiogenesis

Characterization Of A Non-Canonical Function For Threonyl-Trna Synthetase In Angiogenesis

In addition to its canonical role in aminoacylation, threonyl-tRNA synthetase (TARS) possesses pro-angiogenic activity that is susceptible to the TARS-specific antibiotic borrelidin. However, the therapeutic benefit of borrelidin is offset by its strong toxicity to living cells. The removal of a sin...

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Bibliographic Details
Main Author: Mirando, Adam Christopher
Format: Others
Language:en
Published: ScholarWorks @ UVM 2015
Subjects:
Aminoacyl-tRNA Synthetase
Angiogenesis
Endothelial Cells
Enzyme Inhibition
Non-canonical Function
Polyketide
Biochemistry
Cell Biology
Pharmacology
Online Access:http://scholarworks.uvm.edu/graddis/523
http://scholarworks.uvm.edu/cgi/viewcontent.cgi?article=1522&context=graddis

Internet

http://scholarworks.uvm.edu/graddis/523
http://scholarworks.uvm.edu/cgi/viewcontent.cgi?article=1522&context=graddis

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