Refined Inertias Related to Biological Systems and to the Petersen Graph
Many models in the physical and life sciences formulated as dynamical systems have a positive steady state, with the local behavior of this steady state determined by the eigenvalues of its Jacobian matrix. The first part of this thesis is concerned with analyzing the linear stability of the steady...
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| Format: | Others |
| Language: | English en |
| Published: |
2015
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| Online Access: | http://hdl.handle.net/1828/6525 |
| Summary: | Many models in the physical and life sciences formulated as dynamical systems have a positive steady state, with the local behavior of this steady state determined by the eigenvalues of its Jacobian matrix. The first part of this thesis is concerned with analyzing the linear stability of the steady state by using sign patterns, which are matrices with entries from the set {+,-,0}. The linear stability is related to the allowed refined inertias of the sign pattern of the Jacobian matrix of the system, where the refined inertia of a matrix is a 4-tuple (n+, n_-, ; nz; 2np) with n+ (n_) equal to the number of eigenvalues with positive (negative) real part, nz equal to the number of zero eigenvalues, and 2np equal to the number of nonzero pure imaginary eigenvalues. This type of analysis is useful when the parameters of the model are
of known sign but unknown magnitude. The usefulness of sign pattern analysis is illustrated with several biological examples, including biochemical reaction networks, predator{prey models, and an infectious disease model. The refined inertias allowed by sign patterns with specific digraph structures have been studied, for example, for tree sign patterns. In the second part of this thesis, such results on refined inertias are extended by considering sign and zero-nonzero patterns with digraphs isomorphic
to strongly connected orientations of the Petersen graph. === Graduate |
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