Investigação do efeito da inibição farmacológico de IGF1R-IRS1/2 no fenótipo de células leucêmicas BCR-ABL1+

Investigação do efeito da inibição farmacológico de IGF1R-IRS1/2 no fenótipo de células leucêmicas BCR-ABL1+

Leucemia mieloide crônica (LMC) é uma neoplasia hematológica maligna associada à atividade tirosinoquinase da oncoproteína BCR-ABL1. A maioria dos casos de LMC é tratada com sucesso com inibidores tirosinoquinase de BCR-ABL1, mas uma porcentagem significativa de pacientes desenvolve resistência ao f...

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Bibliographic Details
Main Author:	Ribeiro, Renata Scopim
Other Authors:	Traina, Fabíola
Format:	Others
Language:	pt
Published:	Biblioteca Digitais de Teses e Dissertações da USP 2017
Subjects:	BCR-ABL1 Chronic Myeloid Leukemia Insulin receptor substrates IRS1 Leucemia Mieloide Crônica NT157 Substratos do receptor de insulina T315I
Online Access:	http://www.teses.usp.br/teses/disponiveis/17/17154/tde-25042018-161724/

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