| Summary: | A Saúde Bucal está relacionada à exposição ao flúor, hábitos dietéticos e higiênicos menos cariogênicos, além de fatores sócio-econômico-culturais favoráveis. A melhor intervenção farmacêutica constitui-se em formular um agente fluoretado capaz de prevenir e/ou retardar o processo carioso. Procedeu-se a coleta de dentes terceiros molares inclusos que foram fragmentados e adaptados em suportes adequados para serem submetidos aos testes. Determinou-se o protocolo experimental baseado, seqüencialmente, em: avaliação da microdureza das amostras dentárias hígidas; desmineralização das mesmas; avaliação da microdureza das amostras desmineralizadas; remineralização das amostras com diferentes fontes de flúor, em duas concentrações distintas, com três valores de pH e duas posologias diversas; nova avaliação da microdureza no 5 º, 10 º , 15º e 20º dias, seguida de análise por Microscopia Eletrônica de Varredura, com comparação dos resultados quanto à eficácia remineralizante e estabilidade dos enxagüatórios à base de flúor propostos neste experimento. === Oral Health is directly related to the increase of exposure to fluorine, as well as hygienic and dietetic habits that are less cariogenic, and favorable social and economical factors. Consequently, the best pharmaceutical intervention consists in formulating a fluorine agent that is able to prevent and/or retard the carious process. A protocol was executed for the collection of teeth at odontological clinics. After being extracted, those third molar included teeth were, taken to the laboratory so that all the necessary removals of blood deposits, as well as residual tissues, which are unnecessary to the experiment, could be done. The teeth were fragmented and adapted to supports that were adequate to the preparation of the samples that would be tested. The experimental protocol was based on: the evaluation of the hardness of samples of included teeth; demineralization of the samples; the evaluation of the hardness of the samples; the remineralization of the samples with different sources of fluoride, in two different oncentrations, with three pH values and two diverse posologies ; new hardness evaluation on the 5th, 10th, and 15th and 20 th days, followed by an analysis by Electronic Microscopy of Screening with a comparative analysis of the results regarding the efficacy and stability of the mouth rinse propouse in this experiment.
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