Estudos sobre a síntese de novos inibidores da InhA (enoil-acp reductase da Mycobacterium tuberculosis

Estudos sobre a síntese de novos inibidores da InhA (enoil-acp reductase da Mycobacterium tuberculosis

Ao contrário da percepção da sociedade em geral, a tuberculose ainda é uma das mais graves doenças infecciosas da atualidade, estando à frente da HIV/AIDS como uma das maiores causas de morte por infecção. Apesar de todos os avanços recentes, o aparecimento de cepas multirresistentes não permitiu su...

Full description

Bibliographic Details
Main Author:	Gurgel, Alexandre Leal
Other Authors:	Zaim, Marcio Henrique
Format:	Others
Language:	pt
Published:	Biblioteca Digitais de Teses e Dissertações da USP 2017
Subjects:	1-H-2-aminoindol 1-H-2-aminoindole Amide bond Arilamidas Arylamides Carbodiimidas Carbodiimides Ligação amídica Tuberculose Tuberculosis
Online Access:	http://www.teses.usp.br/teses/disponiveis/46/46137/tde-12042018-084312/

Similar Items

Estudos sobre a síntese de novos inibidores da InhA (enoil-acp reductase da Mycobacterium tuberculosis
by: Alexandre Leal Gurgel
Published: (2017)

Azolyacetones as Precursors to Indoles and Naphthofurans Facilitated by Microwave Irradiation with Simultaneous Cooling
by: Morsy Ahmed El-Apasery, et al.
Published: (2009-08-01)

Efeito da cabodiimida e da clorexidina na longevidade da resistência de união de cimento resinoso à dentina radicular e na composição química e estrutura do colágeno dentinário após radioterapia
by: Lopes, Fabiane Carneiro
Published: (2018)

Efeito da biomodificação com carbodiimida e quitosana fosforilada na dentina afetada por cárie
by: Tanta, Gabriela Solano
Published: (2018)

In Vitro Antimycobacterial Activity and Physicochemical Characterization of Diaryl Ether Triclosan Analogues as Potential InhA Reductase Inhibitors
by: Tarek S. Ibrahim, et al.
Published: (2020-07-01)

In Silico Repositioning of Cannabigerol as a Novel Inhibitor of the Enoyl Acyl Carrier Protein (ACP) Reductase (InhA)
by: Luca Pinzi, et al.
Published: (2019-07-01)

Desenvolvimento e implementação de um sistema para a detecção e quantificação absoluta de Mycobacterium tuberculosis usando o gene da proteína enoil redutase NADH-dependente (inhA)
by: D’Oca, Adriano Amaral Montes
Published: (2013)

Crystal structures of N-(3-fluorobenzoyl)benzenesulfonamide and N-(3-fluorobenzoyl)-4-methylbenzenesulfonamide
by: P. A. Suchetan, et al.
Published: (2016-04-01)

A one-pot multistep cyclization yielding thiadiazoloimidazole derivatives
by: Debabrata Samanta, et al.
Published: (2014-12-01)

Synthesis of Quinoxalin-2(1H)-ones and Hexahydroquinoxalin-2(1H)-ones via Oxidative Amidation–Heterocycloannulation
by: Akula Raghunadh, et al.
Published: (2020-07-01)

Crystal structures of three N-(arylsulfonyl)-4-fluorobenzamides
by: P. A. Suchetan, et al.
Published: (2016-04-01)

Investigação da Atividade de Complexos Inorgânicos Inibidores da trans-2-enoil redutase
by: Sales, Francisco
Published: (2011)

Um estudo do efeito da flexibilidade explícita da enzima InhA de M. tuberculosis na docagem molecular dos inibidores etionamida, triclosano e isoniazida-pentacionoferrato II
by: Cohen, Elisângela Machado Leal
Published: (2013)

Estudos da interação da enzima InhA (EC 1.3.1.9) de Mycobacterium tuberculosis H37Rv com análogos do inibidor IQG607
by: Cohen, Elisângela Machado Leal
Published: (2013)

Estudos in silico da interação da enzima InhA de Mycobacterium tuberculosis com pequenas moléculas do tipo fármaco
by: Pauli, Ivani
Published: (2013)

Desenvolvimento e implementa??o de um sistema para a detec??o e quantifica??o absoluta de Mycobacterium tuberculosis usando o gene da prote?na enoil redutase NADH-dependente (inhA)
by: D?Oca, Adriano Amaral Montes
Published: (2015)

Identification of novel inhibitors for Mycobacterium tuberculosis InhA : towards structure-based drug design for tuberculosis
by: Olotu-Umoren, Loyin
Published: (2012)

Efeito do nitrogênio suplementar sobre os componentes de rendimento da soja em condição de estresse hídrico
by: Carlos André Bahry, et al.
Published: (2014-04-01)

Sustainable Synthesis of Novel Arylamide L-Cysteine Methyl Esters Peptidomimetic Derivatives: Inhibitors of Serine and Cysteine-like Proteases
by: Adriana Karla Cardoso Amorim Reis, et al.
Published: (2020-12-01)

A sustainable approach for hydration of nitriles to amides utilising WEB as reaction medium
by: Sameeran Kumar Das, et al.
Published: (2021-01-01)

Synthesis of enantiomerically pure N-(2,3-dihydroxypropyl)arylamides via oxidative esterification
by: Akula Raghunadh, et al.
Published: (2013-10-01)

Virtuelles Screening nach einer neuen Inhibitorklasse der Enoyl-ACP-Reduktase InhA aus Mycobacterium tuberculosis
by: Waltenberger, Constanze Ricarda Maria
Published: (2012)

Um estudo do efeito da flexibilidade expl?cita da enzima InhA de M. tuberculosis na docagem molecular dos inibidores etionamida, triclosano e isoniazida-pentacionoferrato II
by: Cohen, Elis?ngela Machado Leal
Published: (2015)

Estudos da intera??o da enzima InhA (EC 1.3.1.9) de Mycobacterium tuberculosis H37Rv com an?logos do inibidor IQG607
by: Cohen, Elis?ngela Machado Leal
Published: (2015)

Synthesis of Chromium(II) Complexes with Chelating Bis(alkoxide) Ligand and Their Reactions with Organoazides and Diazoalkanes
by: Sudheer S. Kurup, et al.
Published: (2020-01-01)

The ATPase complex of Escherichia coli : studies on the DCCD-binding protein
by: Loo, Tip Wah
Published: (2010)

Trimethylsilylbromoketene and reactions of α-haloacid halides with diisopropylcarbodiimide
by: Owens, Robert Austin
Published: (1977)

Crystal structure of 2-chloro-N-(3-fluorophenyl)acetamide
by: S. Sreenivasa, et al.
Published: (2015-05-01)

Virtual screening de possíveis inibidores da trans-enoil-ACP-redutase de Mycobacterium tuberculosis
by: Araújo, Sergio Xavier Barbosa
Published: (2016)

Desenvolvimento de processos de bioconjugação empregando pontos quânticos fluorescentes de semicondutores II-VI
by: Gonçalves Brasil Júnior, Aluizio
Published: (2014)

Generation Of Electron Deficient Carbodiimides And Their Application In The Guanidine Forming, Zwitterionic 1,3-Diaza-Claisen Rearrangement
by: Walker, Joel
Published: (2017)

N-Aryl-7-hydroxy-5-oxo-2,3-dihydro-1H,5H-pyrido-[3,2,1-ij]quinoline-6-carboxamides. The Synthesis and Effects on Urinary Output
by: Igor V. Ukrainets, et al.
Published: (2018-04-01)

Novel Swine Influenza Virus Reassortants in Pigs, China
by: Yuhai Bi, et al.
Published: (2010-07-01)

Virtual screeningÂde possÃveis inibidores daÂtrans-enoil-ACP-redutase deÂMycobacterium tuberculosis.
by: Sergio Xavier Barbosa AraÃjo
Published: (2013)

Espectrometria de massas combinada a agentes de ligação cruzada para a caracterização estrutural em solução da enzima Enoil-ACP-redutase de Mycobacterium tuberculosis
by: Santos, Anderson Jader Antunes Brizola dos
Published: (2014)

Electrowetting Performances of Novel Fluorinated Polymer Dielectric Layer Based on Poly(1H,1H,2H,2H-perfluoroctylmethacrylate) Nanoemulsion
by: Jiaxin Hou, et al.
Published: (2017-06-01)

InvestigaÃÃo da Atividade de Complexos InorgÃnicos Inibidores da trans-2-enoil redutase
by: Francisco Adilson Matos Sales
Published: (2008)

Analytical Method Development of Fluorinated Silanes using Mass Spectrometry
by: Eklundh Odler, Tea
Published: (2018)

Ketene Carbodiimide Cycloadditions
by: Dorsey, Edwin Darrell
Published: (1970)

A enzima 2-trans-enoil-ACP (CoA) redutase de mycobacterium tuberculosis: estudos de ligação e inibição por um complexo inorgânico derivado da isoniazida
by: Vasconcelos, Igor Bordin
Published: (2013)