Análise estereosseletiva do cloridrato de cis-tramadol e de suas impurezas em matéria-prima e formulação farmacêutica

Análise estereosseletiva do cloridrato de cis-tramadol e de suas impurezas em matéria-prima e formulação farmacêutica

O cloridrato de tramadol, analgésico sintético de ação central, possui dois centros quirais: o isômero cis é ativo e o isômero trans é uma impureza de processo. Ambos os enantiômeros do cloridrato de cis-tramadol contribuem para o efeito analgésico, mas através de mecanismos diferentes, complementar...

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Bibliographic Details
Main Author:	Bernardo, Naíssa Prévide
Other Authors:	Bonato, Pierina Sueli
Format:	Others
Language:	pt
Published:	Biblioteca Digitais de Teses e Dissertações da USP 2008
Subjects:	chiral stationary phase cis-tramadol hydrochloride enantiomers cromatografia líquida de alta eficiência enantiômeros do cloridrato de cis-tramadol fase estacionária quiral formulação farmacêutica high-performance liquid chromatography impurezas impurities matéria-prima pharmaceutical formulation raw material
Online Access:	http://www.teses.usp.br/teses/disponiveis/60/60134/tde-10122008-222618/

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