Identification of protein targets of nevirapine reactive metabolites using click chemistry and mass spectrometry-based differential proteomics

Identification of protein targets of nevirapine reactive metabolites using click chemistry and mass spectrometry-based differential proteomics

Abstract : Adverse drug reactions (ADRs) are undesirable effects caused after administration of a single dose or prolonged administration of drug or result from the combination of two or more drugs. Idiosyncratic drug reaction (IDR) is an adverse reaction that does not occur in most patients treated...

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Bibliographic Details
Main Author: Eloraby, Ghada
Other Authors: Klarskov, Klaus
Language:English
Published: Université de Sherbrooke 2016
Subjects:
Nevirapine
HIV
IDR
Hypersensitivity
Click chemistry
Brown Norway rat
Western blotting
Danger hypothesis
Névirapine
VIH
Hypersensibilité
Chimie Click
Western blot
Spectrométrie de masse et stress oxidatif
Online Access:http://hdl.handle.net/11143/8995

Internet

http://hdl.handle.net/11143/8995

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