Desarrollo y análisis de algoritmos probabilísticos para la reconstrucción de modelos metabólicos a escala genómica

This doctoral project is focused on the development and analysis of algorithms for the reconstruction of genome-scale metabolic models, such algorithms include decision-making based on probabilistic criteria. As a fundamental result of the doctoral research, the web application Computational Platfor...

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Bibliographic Details
Main Author: Reyes Chirino, Raymari
Other Authors: Fernández de Córdoba Castellá, Pedro José
Format: Doctoral Thesis
Language:Spanish
Published: Universitat Politècnica de València 2013
Subjects:
Online Access:http://hdl.handle.net/10251/34344
Description
Summary:This doctoral project is focused on the development and analysis of algorithms for the reconstruction of genome-scale metabolic models, such algorithms include decision-making based on probabilistic criteria. As a fundamental result of the doctoral research, the web application Computational Platform to Access Biological Information (COPABI), which can reconstruct genome-scale metabolic models of biological systems, has been developed. During its computational implementation, it was followed the methodology used for the reconstruction of the first genome-scale metabolic model of a photosynthetic microorganism, the Synechocystis sp. PCC6803. Different mathematical algorithms were applied to compare the models that were automatically generated by COPABI with those published in the literature for different species. === El presente proyecto doctoral se ha centrado en el desarrollo y análisis de algoritmos para la reconstrucción de modelos metabólicos a escala genómica; tales algoritmos incluyen la toma de decisiones a partir de criterios probabilísticos. Como resultado fundamental de la investigación doctoral cabe destacar que se ha desarrollado la aplicación web Computational Platform to Access Biological Information (COPABI) que permite reconstruir modelos metabólicos a escala genómica de sistemas biológicos. Durante su implementación computacional, se ha seguido la metodología usada para la reconstrucción del primer modelo metabólico a escala genómica de un microorganismo fotosintético, la Synechocystis sp. PCC6803. Se aplicaron diferentes algoritmos matemáticos para comparar los modelos generados automáticamente por COPABI con los publicados en la literatura para diferentes especies. === Reyes Chirino, R. (2013). Desarrollo y análisis de algoritmos probabilísticos para la reconstrucción de modelos metabólicos a escala genómica [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/34344 === TESIS