Evaluation of Strategies to Improve In Vitro Mutagenicity Assessment: Alternative Sources of S9 Exogenous Metabolic Activation and the Development of an In Vitro Assay Based on MutaMouse Primary Hepatocytes
In vitro genetic toxicity tests using cultured bacterial or mammalian cells provide a cost- and time-effective alternative to animal tests. Unfortunately, existing in vitro assays are not always reliable. This is in part due to the limited metabolic capacity of the cells used, which is often critica...
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| Format: | Others |
| Language: | en |
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Université d'Ottawa / University of Ottawa
2019
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| Online Access: | http://hdl.handle.net/10393/39340 http://dx.doi.org/10.20381/ruor-23587 |