Searching for Synergy: FAK Inhibition in Metastatic Breast Cancer Treatment

Searching for Synergy: FAK Inhibition in Metastatic Breast Cancer Treatment

Breast cancer is the most common cancer among Canadian women and 14-20% will develop lethal metastases within 5 years. A potential novel therapeutic target is Focal Adhesion Kinase (FAK), a cytoplasmic tyrosine kinase. FAK’s expression is inversely correlated with survival and is known to regulate c...

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Bibliographic Details
Main Author:	Conway, Brianna
Other Authors:	Addison, Christina
Language:	en
Published:	Université d'Ottawa / University of Ottawa 2018
Subjects:	breast cancer FAK chemotherapy combination therapy PF-562271 topoisomerase inhibition ROS treatment metastatic
Online Access:	http://hdl.handle.net/10393/37304 http://dx.doi.org/10.20381/ruor-21576

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